Fig. 5. (a) Co-crystal structure of 1 (in pink) and ATP bound to CK2α (PDB: ; 5CSH)19 and (b) surface representation of CK2α with 1 bound. (c) Co-crystal structure of 21 (in green) bound to CK2α. The binding mode of ATP (grey) in the ATP site when 1 is bound is superimposed upon the structure. (d) Co-crystal structure of 21 (in green) bound to the surface representation of CK2α. (e) Co-crystal structure of 22 (in blue) bound to CK2α. The binding mode of ATP (grey) in the ATP site when 1 is bound is superimposed upon the structure. (f) Co-crystal structure of 22 (in blue) bound to the surface representation of CK2α.