Table 4. Studies on the benzimidazole substitution.

Compound	R	R′	Inhibition @10 μM (%)	GI50 a (μM)	PDB
23	H	H	33 (IC50 18)	10	5OSZ
24	Me	H	45	—	5OT5
25	NO2	H	50	—	50TD
26	OMe	H	52 (IC50 8)	11	5OTH
27	H	Me	38	—	5OTI
28	H	NO2	36	—
29	H	OMe	64 (IC50 7)	11	5OTL
30	H	Cl	50	—	5OTO

^aInhibition of proliferation tested in HCT116 cell line.