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. 2018 Feb 20;9(11):3041–3049. doi: 10.1039/c7sc05122k

Table 5. Optimization of ring B.

Inline graphic
Compound R R′ Inhibition @10 μM (%) PBD
23 Cl H 33 (IC50 18) 5OSZ
CAM4712 Cl Cl 80 (IC50 7) 5OTY
31 Me H 30 5OYF
32 CF3 H 23 6EHU
33 OMe H 41 5OTQ
34 OCF3 H 39 n.a.