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. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: J Pharm Sci. 2017 Dec 21;107(5):1269–1281. doi: 10.1016/j.xphs.2017.12.015

comparison of B₂₂/B_22,ST as a function of TIS between experimental (symbols) and simulated values (shaded areas) using the HEXA model at pH 5 for buffer-only (panel A) and 5% w/w added sucrose (panel B) and at pH 6.5 for buffer-only (panel C) and 5% w/w added sucrose (panel D). Inset: surface response of ARD values as a function of ε_SR and ψ for each respective formulation.

comparison of B₂₂/B_22,ST as a function of TIS between experimental (symbols) and simulated values (shaded areas) using the HEXA model at pH 5 for buffer-only (panel A) and 5% w/w added sucrose (panel B) and at pH 6.5 for buffer-only (panel C) and 5% w/w added sucrose (panel D). Inset: surface response of ARD values as a function of ε_SR and ψ for each respective formulation.