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. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: J Pharm Sci. 2017 Dec 21;107(5):1269–1281. doi: 10.1016/j.xphs.2017.12.015

IgG1 values as a function of sucrose concentrations at 25 °C and pH 5 (panel A) and pH 6.5 (panel B) for quaternary solutions of water, IgG1, sucrose and 10 mM acetate (panel A) or histidine (panel B) buffer. The dashed lines represent the linear fits to extract (G₁₂-G₂₃) from equation 3 with the assumption that $c_{4} {\hat{V}}_{4}$ is negligible. Shaded areas represent the 95% confidence level of each individual linear fit.

IgG1 values as a function of sucrose concentrations at 25 °C and pH 5 (panel A) and pH 6.5 (panel B) for quaternary solutions of water, IgG1, sucrose and 10 mM acetate (panel A) or histidine (panel B) buffer. The dashed lines represent the linear fits to extract (G₁₂-G₂₃) from equation 3 with the assumption that $c_{4} {\hat{V}}_{4}$ is negligible. Shaded areas represent the 95% confidence level of each individual linear fit.