Table 2.
Characteristics of patients when eGFR first fell below 35 mL/min/1.73 m2 by change in BMI z score category
| Characteristic | Significant Weight Loss (n=66) |
Moderate Weight Loss (n=93) |
Maintained Weight (n=51) |
Gained Weight (n=58) |
P value |
|---|---|---|---|---|---|
|
| |||||
| Age category | 0.2 | ||||
| < 5 y | 3 (5%) | 3 (3) | 3 (6) | 6 (10) | |
| 5-<12 y | 17 (26) | 39 (42) | 16 (31) | 19 (33) | |
| ≥12 y | 46 (70) | 51 (55) | 32 (63) | 33 (57) | |
|
| |||||
| Race | 0.1 | ||||
| White | 46 (70) | 71 (76) | 27 (53) | 35 (60) | |
| Black | 11 (17) | 13 (14) | 13 (26) | 11 (19) | |
| Other | 9 (14) | 9 (10) | 11 (22) | 12 (21) | |
|
| |||||
| Male sex | 50 (76) | 61 (66) | 32 (63) | 34 (59) | 0.2 |
|
| |||||
| Cause of CKD | 0.04 | ||||
| Glomerular | 21 (32) | 12 (13) | 8 (16) | 9 (16) | |
| CAKUT | 43 (65) | 71 (76) | 40 (78) | 46 (79) | |
| Other | 2 (3) | 10 (11) | 3 (6) | 3 (5) | |
|
| |||||
| Maternal education* | 0.8 | ||||
| High school | 32 (50) | 39 (43) | 21 (43) | 22 (39) | |
| Some college | 13 (20) | 25 (28) | 12 (25) | 19 (34) | |
| College graduate | 19 (30) | 27 (30) | 16 (33) | 15 (27) | |
|
| |||||
| Income* | 0.5 | ||||
| <$24,000/y | 19 (30) | 17 (19) | 8 (16) | 16 (28) | |
| $24,000–$75,000/y | 10 (16) | 16 (18) | 9 (18) | 12 (21) | |
| >$75,000/y | 35 (55) | 55 (63) | 32 (65) | 29 (51) | |
|
| |||||
| Ever had an NG or G tube* | 1 (2) | 2 (2) | 4 (8) | 4 (7) | 0.2 |
|
| |||||
| Fair/poor appetite in last 7 d when eGFR first < 35 mL/min/1.73 m2* # | 7 (21) | 6 (7) | 2 (4) | 5 (9) | 0.4 |
|
| |||||
| BMI z score when eGFR first< 35 mL/min/1.73 m2 | 0.32 [−0.3 to 1.1] | 0.45 [−0.5 to 1.2] | 0.56 [0 to 1.4] | −0.3 [−0.8 to 0.2] | <0.001 |
|
| |||||
| Most recent BMI z score | −0.44 [−1.1 to 0.2] | 0.05 [−0.9 to 0.8] | 0.76 [0.2 to 1.5] | 0.37 [−0.2 to 0.9] | <0.001 |
|
| |||||
| Systolic BP* z score when eGFR first <35 mL/min/1.73 m2 | 0.35 ± 1.3 | 0.33 ± 1.3 | 0.28 ± 1.1 | 0.22 ± 1.3 | 0.9 |
|
| |||||
| Serum albumin when eGFR first <35 mL/min/1.73 m 2*, g/dL | 4.1 ± 0.6 | 4.3 ± 0.3 | 4.2 ± 0.4 | 4.3 ± 0.4 | 0.1 |
|
| |||||
| Most recent serum albumin (g/dL)* | 4.2 ± 0.5 | 4.4 ± 0.4 | 4.3 ± 0.4 | 4.2 ± 0.5 | 0.1 |
|
| |||||
| Proteinuria (PCR ≥ 2g/g)* | 22 (34.9) | 18 (19.8) | 11 (22.9) | 12 (21.8) | 0.2 |
|
| |||||
| Hb* when eGFR first <35 mL/min/1.73m2 | 12.1 ± 1.7 | 12.0 ± 1.4 | 12.2 ± 1.6 | 12.1 ± 1.8 | 0.9 |
Note: n=268. Values for categorical variables are given as number (column percentage); for continuous variables, as mean ± standard deviation or median [interquartile range].
Data for maternal education missing in n=8; income missing or unknown in n=10; NG tube missing in n= 15; albumin missing in n=7; SBP missing in n=6; appetite missing in n=162; serum albumin at baseline missing in n=3 and most recent missing in n=7; proteinuria missing in n=11; hemoglobin missing in n=4
BMI, body mass index; CAKUT, congenital anomalies of the kidney and urinary tract; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; G, gastrostomy; NG, nasogastric; Hb, hemoglobin; PCR, protein-creatinine ratio
By self- or parent-report