Figure 4.
During early infection CD80/CD86 signaling contributes to cytokine production. C57BL/6J WT and Cd80Cd86−/− mice were intranasally infected with 4 × 107 cfu of S. aureus for 4 h. A) Bacterial counts from BALF and lung homogenate. External body temperatures prior to euthanasia. B) Neutrophil numbers in BALF. C) Cytokine levels in BALF. n=2 for uninfected animals, WT infected n=11 and Cd80Cd86−/− infected n=12. Each point represents a mouse. Lines display medians. Graphs display means with standard error. **P<0.01 and *P<0.05.