Skip to main content
. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Stroke. 2018 Mar 28;49(5):1232–1240. doi: 10.1161/STROKEAHA.117.020356

Figure 5. Overexpression of PDGFB increases pericyte covered bAVM vessels.

Figure 5

A. Representative confocal images of brain sections stained with antibodies specific to CD31 (an endothelial cell-marker, red) and CD13 (a pericyte-marker, green). Scale bars: 100 μm. B. Quantification of the percentage of endothelial cells (ECs) covered by pericypes. All mice were Alk12f/2f mice and were treated with AAV-VEGF to induce brain angiogenesis. Ad-GFP+Lenti-GFP: Controls for normal angiogenesis; Ad-GFP+Lenti-PDGFB: Overexpressing PDGFB in angiogenic brain; Ad-Cre+Lenti-GFP: Untreated bAVM; Ad-Cre+Lenti-PDGFB; Overexpression of PDGFB in bAVM. N=6. P values were determined by one-way ANOVA followed by Sidak’s multiple comparisons.