Table 4.
Sex-adjusted hazard ratios for the most important combinations of two symptoms, with or without additional symptomsa, N = 61 337
| Symptom combinations | New abdominal cancer diagnosed within 180 days, n= 175 | Male, n= 90 | Female, n= 85 | No cancer, n= 61 162 | HR | 95% CI | HR, male | HR, female |
|---|---|---|---|---|---|---|---|---|
| No abdominal symptoms | 99 | 62 | 37 | 55 060 | 1.0 | Ref | 1.0 | 1.0 |
| Abdominal pain, upper part + lower part | 7 | 3 | 4 | 543 | 8.1 | 3.7 to 17.6 | 6.7 | 11.1 |
| Abdominal pain, upper part + constipation | 7 | 4 | 3 | 194 | 22.2 | 10.1 to 48.5 | 19.8 | 26.1 |
| Abdominal pain, upper part + diarrhoea | 5 | 3 | 2 | 361 | 11.5 | 4.6 to 28.8 | 17.6 | 8.8 |
| Abdominal pain, upper part + distended abdomen | 11 | 5 | 6 | 458 | 15.0 | 8.0 to 28.3 | 12.4 | 19.9 |
| Abdominal pain, upper part + increased belching | 9 | 5 | 4 | 263 | 23.2 | 11.4 to 46.7 | 21.1 | 26.1 |
| Abdominal pain, upper part + acid regurgitations | 8 | 4 | 4 | 440 | 13.3 | 6.3 to 27.6 | 16.6 | 12.9 |
| Abdominal pain, upper part + rectal bleeding | 6 | 3 | 3 | 47 | 64.2 | 26.9 to 153.1 | 57.5 | 100.5 |
| Abdominal pain, upper part + other abdominal problem | 7 | 3 | 4 | 200 | 22.3 | 10.2 to 48.8 | 19.6 | 24.2 |
| Abdominal pain, lower part + constipation | 7 | 3 | 4 | 296 | 12.6 | 5.8 to 27.5 | 9.2 | 19.7 |
| Abdominal pain, lower part + distended abdomen | 6 | 3 | 3 | 449 | 7.9 | 3.4 to 18.0 | 7.1 | 9.6 |
| Abdominal pain, upper part + lack of appetite | 14 | 6 | 8 | 457 | 17.2 | 9.7 to 30.5 | 14.9 | 22.4 |
| Abdominal pain, upper part + unusual tirednesss | 10 | 4 | 6 | 342 | 16.8 | 8.6 to 32.8 | 13.4 | 23.3 |
| Abdominal pain, upper part + unexpected weight loss | 5 | 3 | 2 | 130 | 21.6 | 8.6 to 54.2 | 30.8 | 18.2 |
a
Criteria for analyses: all combinations to have at least 50 patients presenting with that combination and at least five cases of cancer with that combination. Multivariate Cox analyses, with each row representing one separate model. Patients without symptoms as reference group. Because the combinations are with or without additional symptoms, some of them may occur in more than one model. HR = hazard ratio. Ref = reference.