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. 2018 Feb 22;3(4):e95824. doi: 10.1172/jci.insight.95824

Figure 12. Inhibiting HDACs with SAHA enhances autophagy signaling in post-MI myocardium.

Figure 12

Ten- to 12-week-old male CD1 mice were subjected to either sham (control) or ligation of the coronary artery surgery and received daily i.p. injections of DMSO (vehicle-control) or HDAC inhibition, SAHA (25 mg/kg). Seven days after MI, mice were euthanized. Localization and abundance of autophagy markers, ATG-7, and the LC3II complex in the border zone of infarction, 10×magnification, scale bars: 100 μm. Sham n = 6 and MI n = 8.