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. 2018 Feb 22;3(4):e96006. doi: 10.1172/jci.insight.96006

Figure 4. Stimulation of NOsGC improves diastolic function and regional diastolic compliance.

Figure 4

(A) Ejection fraction (EF) values of the left ventricle were preserved in vehicle-treated dTGR. BAY 41-8543 administration led to a significant increase in EF (**P < 0.01; 1-way ANOVA with Dunn’s post hoc test; data expressed as mean ± SEM; SD, n = 5; vehicle, n = 6; BAY 41-8543, n = 10). (B) Ratio of peak E velocity to peak A velocity (E/A) was slightly but not significantly increased in vehicle-treated dTGRs (P = 0.1).The E/A ratio was reduced by BAY 41-8543 treatment (P = 0.05; 1-way ANOVA with Tukey’s post hoc test; data expressed as mean ± SEM; SD, n = 5; vehicle, n = 8; BAY 41-8543, n = 10). (C) Mitral valve E-wave deceleration time (DTT) was shortened in vehicle-treated dTGR (*P < 0.05; 1-way ANOVA with Tukey’s post hoc test; data expressed as mean ± SEM; SD, n = 5; vehicle, n = 8; BAY 41-8543, n = 10). (D) Isovolumetric relaxation time (IVRT) was prolonged in vehicle-treated dTGRs. Administration of BAY 41-8543 diminished the IVRT (*P < 0.05; 1-way ANOVA with Tukey’s post hoc test; data expressed as mean ± SEM; SD, n = 5; vehicle, n = 6; BAY 41-8543, n = 10). (E) Global longitudinal strain (GLS) was reduced in vehicle-treated dTGR. BAY 41-8543 treatment led to an increase in GLS (*P < 0.05; ***P < 0.001; 1-way ANOVA with Tukey’s post hoc test; data expressed as mean ± SEM; SD, n = 4; vehicle, n = 6; BAY 41-8543, n = 9). (F) Global circumferential strain (GCS) was decreased in vehicle-treated dTGR. BAY 41-8543 treatment led to an increase in GCS (**P < 0.01; 1-way ANOVA with Tukey’s post hoc test; data expressed as mean ± SEM; SD, n = 4; vehicle, n = 7; BAY 41-8543, n = 9). (G) Global radial strain (GRS) was lower in vehicle-treated dTGR. BAY 41-8543 treatment led to an increase in GRS compared with vehicle but did not reach (P = 0.07) significance (*P < 0.05; 1-way ANOVA with Tukey’s post hoc test; data expressed as mean ± SEM, SD, n = 4; vehicle, n = 8; BAY 41-8543, n = 10). (H) For assessment of regional myocardial strain in the parasternal short axis, the left ventricle was divided into 6 segments. (I) Time-to-peak circumferential strain is elevated in vehicle-treated dTGR. BAY 41-8543 administration led to a shorter time-to-peak strain in circumferential axis (#P < 0.5; 2-way ANOVA; data expressed as mean ± SEM; SD, n = 4; vehicle, n = 6; BAY 41-8543, n = 10). (J) Time-to-peak radial strain was elevated in vehicle-treated dTGR. BAY 41-8543 administration led to a shorter time-to-peak strain in radial axis (#P < 0.5; 2-way ANOVA; data expressed as mean ± SEM; SD, n = 4; vehicle, n = 6; BAY 41-8543, n = 10).