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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2018 Mar 24;42(5):939–951. doi: 10.1111/acer.13615

Figure 11. Apremilast reduces acute functional tolerance to ethanol.

Figure 11

(A) Time to regain the ability to remain on the rotarod for 60s after the first (1.75 g/kg) and second (2 g/kg) ethanol injection in saline-pretreated and apremilast (20 mg/kg)-pretreated male and female mice. (B) BECs measured at the time of regaining motor function after the first and second ethanol injections in saline-pretreated and apremilast-pretreated male and female mice. (C) Difference in recovery time between the second and first ethanol injections. (D) Acute functional tolerance (AFT) to ethanol measured as the difference in BECs (mg/dl) after two ethanol injections (BEC2 - BEC1). (**p < 0.01 and ****p < 0.0001 compared with saline control by Bonferroni post-hoc (A, B) or t-tests (C, D); n =16-18 per group).