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(A) Changes in saccharin (0.15% w/v) consumption produced by injection of saline or apremilast (20 mg/kg) expressed as a percent of the control trial (trial 0). (B) Preference for saccharin during extinction in saline-pretreated and apremilast-pretreated male and female mice (****p < 0.0001 compared with saline control by Bonferroni post-hoc tests; n= 12 per group).
