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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2018 Mar 24;42(5):939–951. doi: 10.1111/acer.13615

Figure 5. Effect of apremilast on conditioned place avoidance to ethanol (2 g/kg).

Figure 5

(A) The CPA score was significantly less than 0 (theoretical mean) only in the apremilast (20 mg/kg)-pretreated group (*p < 0.05 compared with no CPA by one-sample t-test), and the CPA score in the apremilast-pretreated group was lower compared with the score in the saline-pretreated group (p < 0.05, two-tailed t-test). (B) Time spent on the bar floor when paired with saline [Bar-] was greater than time spent on the bar floor when paired with ethanol [Bar+] after pretreatment with saline or apremilast (n= 17-18 per group).