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(A) Handling-induced convulsion (HIC) scores were measured every hour after injection of ethanol (4 g/kg) in male and female mice pretreated with saline or 20 mg/kg of apremilast. Horizontal lines represent the basal HIC level for control (dashed line) and apremilast-pretreated (solid line) groups. (B) Area under the curve (below basal) and (C) area above the curve (above basal; n= 9 per group).
