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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2018 Mar 13;42(5):861–868. doi: 10.1111/acer.13614

Table 2. Genomewide significant SNPs associated with different traits.

Trait Lead SNP and
rs671
A1/A2 P_GSA P_MEGA P_meta Beta (se) Freq Gene GWS SNPs in LD region (r2 >
0.2 with lead SNP)
Flushing rs143894582 (chr12:112906873) CA/C 8.33×10−8 2.76×10−8 2.01×10−14 1.70 (0.22) 0.08 PTPN11 chr12:111367244–112930475 (23 SNPs)
rs671 (chr12:112241766, r2 = 0.82 with rs143894582) A/G 2.94×10−8 1.96×10−8 5.15×10−14 1.49 (0.20) 0.09 ALDH2
MAXDRINKS rs149212747 (chr12: 111836771) A/AC 9.03×10−9 4.59×10−5 1.61×10−12 0.59 (0.08) 0.91 SH2B3a chr12:111609727–112930475 (15 SNPs)
rs671 (r2 = 0.92 with rs149212747) G/A 4.02×10−8 6.05×10−4 1.25×10−10 0.53 (0.08) 0.91 ALDH2
Alcohol dependence rs149212747 A/AC 1.54×10−5 6.96×10−6 5.80×10−10 0.91 (0.15) 0.91 SH2B3a chr12:111836771–112930475 (12 SNPs)
rs671 (r2 = 0.92 with rs149212747) G/A 1.45×10−5 7.99×10−5 4.46×10−9 0.84 (0.14) 0.91 ALDH2
a

SH2B3 is less than 10kb downstream from rs149212747.