Table 2. Genomewide significant SNPs associated with different traits.
| Trait | Lead SNP and rs671 |
A1/A2 | P_GSA | P_MEGA | P_meta | Beta (se) | Freq | Gene | GWS SNPs in LD region (r2 > 0.2 with lead SNP) |
|---|---|---|---|---|---|---|---|---|---|
| Flushing | rs143894582 (chr12:112906873) | CA/C | 8.33×10−8 | 2.76×10−8 | 2.01×10−14 | 1.70 (0.22) | 0.08 | PTPN11 | chr12:111367244–112930475 (23 SNPs) |
| rs671 (chr12:112241766, r2 = 0.82 with rs143894582) | A/G | 2.94×10−8 | 1.96×10−8 | 5.15×10−14 | 1.49 (0.20) | 0.09 | ALDH2 | ||
| MAXDRINKS | rs149212747 (chr12: 111836771) | A/AC | 9.03×10−9 | 4.59×10−5 | 1.61×10−12 | 0.59 (0.08) | 0.91 | SH2B3a | chr12:111609727–112930475 (15 SNPs) |
| rs671 (r2 = 0.92 with rs149212747) | G/A | 4.02×10−8 | 6.05×10−4 | 1.25×10−10 | 0.53 (0.08) | 0.91 | ALDH2 | ||
| Alcohol dependence | rs149212747 | A/AC | 1.54×10−5 | 6.96×10−6 | 5.80×10−10 | 0.91 (0.15) | 0.91 | SH2B3a | chr12:111836771–112930475 (12 SNPs) |
| rs671 (r2 = 0.92 with rs149212747) | G/A | 1.45×10−5 | 7.99×10−5 | 4.46×10−9 | 0.84 (0.14) | 0.91 | ALDH2 |
a
SH2B3 is less than 10kb downstream from rs149212747.