Figure 1.

Within-subject measures of dopamine synthesis capacity and D2/3 receptor binding. (a) [¹⁸F]FMT K_i signal reflecting dopamine synthesis capacity was measured throughout striatum. The axial slice illustrates the extent of the striatal K_i signal for a representative subject overlaid on the subject’s native space T1 MPRAGE. (b) [¹¹C]raclopride BP_ND displayed for placebo (baseline) scan as well as post-methylphenidate scan for the same representative subject. Methylphenidate administration reduced [¹¹C]raclopride BP_ND. (c) Striatal regions showing significantly reduced [¹¹C]raclopride BP_ND following methylphenidate administration across all participants. The t-map for the paired t-test comparing baseline and post-methylphenidate [¹¹C]raclopride BP_ND is displayed on the normalized mean T1 MPRAGE for all subjects.