Figure 1.

Riluzole inhibits cocaine reinstatement without impairment on locomotor activity or sucrose reinstatement. (a) Schematic of self-administration (SA), extinction (Ext), and reinstatement testing. At 30 min before each extinction or reinstatement session, rats were injected intraperitoneally (i.p.) with 4 mg/kg riluzole, 1 mg/kg riluzole, or vehicle. (b) Active lever presses and infusions for all rats across groups during the last 7 days of cocaine SA and throughout extinction training. Extinction pressing is shown separately for respective treatment groups. *Indicates 4 mg/kg riluzole-treated significantly different from vehicle-treated. (c, d) Active lever presses for each group during the last day of extinction, and during cue- and cocaine-primed reinstatement tests. (e) Active lever pressing and number of sucrose pellets during sucrose SA and Ext. (f) Active lever presses during the last day of Ext and during the cue-primed sucrose reinstatement test. (g) Open field locomotor activity of Saline–Vehicle, Cocaine–Vehicle, and Cocaine–4 mg/kg rats.