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. 2017 Nov 8;43(6):1212–1223. doi: 10.1038/npp.2017.244

Figure 2.

Figure 2

Riluzole prevents cocaine-induced intrinsic changes in PL pyramidal neuron. (a) Active lever presses and infusions during cocaine or saline SA for all rats from which neurons were recorded in PL and IL. Before each extinction (Ext) session, rats were injected i.p. with 4 mg/kg riluzole (Cocaine–4 mg/kg, N=14; Saline–4 mg/kg, N=8) or vehicle (Cocaine–Vehicle, N=12; Saline–Vehicle, N=13). *Indicates significant difference between Cocaine–Vehicle and Cocaine–4 mg/kg groups. (b) Example traces from each group. (c) Number of spikes evoked by depolarizing steps of increasing current in the four groups (Cocaine–4 mg/kg, N=14, n=26; Saline–4 mg/kg, N=8, n=16; Cocaine–Vehicle, N=12, n=22; Saline–Vehicle, N=13, n=25). (d) Bar graph shows the maximum number of evoked spikes at any current step. (e) Duration of the first ISI from maximum number of spikes. (f) Group data of the fAHP measured after the second evoked spike. For (d–f), x axis indicates the self-administration group, and legend indicates treatment with riluzole or vehicle. In (f), *p<0.05 as compared with all other groups in (f). N=number of rats; n=number of cells.