Table 1. Electrophysiological Properties of PL and IL Neurons.
| Groups | Vm(mV) | Rin(MΩ) | Rheobase (pA) | Threshold (mV) | sAHP (mV) | mAHP (mV) |
|---|---|---|---|---|---|---|
| PL | ||||||
| Saline–Vehicle | −66.8±1.6 | 106.0±13.3 | 117.7±12.3* | 31.2±1.4 | −0.5±0.1 | −0.8±0.2 |
| Saline–4 mg/kg | −71.8±1.3 | 90.1±6.7 | 90.1±7.8 | 30.9±1.2 | −0.8±0.3 | −1.6±0.5 |
| Cocaine–Vehicle | −69.9±1.3 | 87.2±7.7 | 101.8±10.1 | 29.8±1.1 | −0.6±0.2 | −1.1±0.2 |
| Cocaine–4 mg | −65.7±1.3 | 81.8±5.0 | 110.8±10.0 | 31.5±1.3 | −0.8±0.2 | −1.1±0.2 |
| IL | ||||||
| Saline–Vehicle | −65.8±1.3 | 93.9±5.6 | 81.9±5.2* | 31.9±0.8 | −1.8±0.3 | −2.2±0.3 |
| Saline–4 mg/kg | −68.1±1.8 | 115.0±10.0 | 72.0±9.5 | 30.4 ±1.3 | −1.0±0.4 | −1.6±0.4 |
| Cocaine–Vehicle | −66.6±1.0 | 108.9±13.3 | 94.8±9.8 | 30.7±0.9 | −1.46±0.3 | −2.2±0.4 |
| Cocaine–4 mg | −68.5±1.5 | 90.8±6.8 | 78.0±6.7* | 28.5±1.0 | −1.4± 0.2 | −2.3±0.3 |
Two-way ANOVA showed no difference between the groups for any measure per brain subregion (p>0.05). Two-way ANOVA showed a treatment main effect in the amount of depolarizing current necessary to evoke an action potential (rheobase) between subregions (F(3, 190)=5.128, p<0.05). Tukey's post hoc multiple comparisons test showed that PL–Saline–Vehicle neuron rheobase is significantly different compared with IL neuron rheobase from Saline–Vehicle and Cocaine–4 mg/kg groups (*p<0.05).