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. 2017 Dec 20;43(6):1373–1384. doi: 10.1038/npp.2017.279

Figure 3.

Figure 3

Pharmacological disconnection of the vCA1-IL pathway decreased context-induced reinstatement of heroin seeking. (a) Left, an overview of the disconnection procedure. Right, histological sites of cannula placements in the IL and vCA1. Scale bar, 500 μm. (b) Number of nose-pokes during the context-induced reinstatement tests after injections of B+M in the vCA1 and Tat-GluA23A or Tat-GluA23Y in the ipsilateral or contralateral side in the IL. Two-way ANOVA, *P< 0.05 vs the number of inactive nose-poke of each group; #P<0.05 vs the number of active nose-poke in the contralateral Tat-GluA23Y group, n=6–9 per group. 3A and 3Y stand for Tat-GluA23A and Tat-GluA23Y, respectively. (c) Locomotor activity (distance traveled) during 20 min bins in the 1-h session after B+M injection in the vCA1 and Tat-GluA23Y injection in the contralateral side in the IL, n=7–9 per group. (d) Saccharin SA training, n=14 per group. (e) Number of saccharin reinforcers during the saccharin SA test after B+M/Tat-GluA23Y contralateral disconnection treatment, n=7 per group. Data are depicted as the mean±SEM.