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. 2017 Dec 20;43(6):1373–1384. doi: 10.1038/npp.2017.279

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Chemogenetic silencing of the vCA1–IL pathway decreased context-induced reinstatement of heroin seeking. (a) Left, an overview of AAV injection sites in the vCA1 and the IL. Right, representative expression of AAV8-hSyn-hM4D (Gi)-mCherry in cell bodies of the vCA1 (top) and axon terminals in both the PL and IL (bottom) 6 weeks after AAV injected in bilateral vCA1. Scale bar (left) 500 μm and (right) 100 μm. (b) Number of active nose-pokes in rats with hM4D(Gi) or mCherry virus expression during the reinstatement testing after bilateral saline or CNO treatment in the IL. Two-way ANOVA, *P<0.05 vs the mCherry+CNO group; ^#P<0.05 vs the hM4D(Gi)+Saline group, n=7 per group. (c) Locomotor activity (distance traveled) during 20 min bins in the 1-h session after bilateral saline or CNO treatment in the IL. (d) Saccharin SA training, n=14. (e) Number of saccharin reinforcers during the saccharin SA test after bilateral saline or CNO treatment in the IL, n=7 per group. Data are depicted as mean±SEM.