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. 2017 Dec 20;43(6):1297–1307. doi: 10.1038/npp.2017.281

Figure 4.

Figure 4

Inhibition of ventral hippocampal LTP increases generalization of conditioned fear in offspring of low LG dams. Left: reconstruction of coronal cross-section depicting the locations of verified cannulae tip placements in the ventral hippocampus. Right: effect of ventral hippocampal infusion of Tat-GluA1ct on fear-associated freezing following cued fear conditioning in response to a neutral stimulus (CS−) and the conditioned stimulus (CS+). Bar graphs denote mean+SEM of percent of time during each stimulus presentation period spent freezing. Offspring of low LG mothers infused with Tat-GluA1ct in their ventral hippocampus froze significantly more in response to CS− than offspring of low LG mothers infused with Tat-Ctrl when presented with CS−. (Tat-Ctrl-infused offspring of low LG dams: n=9 rats; Tat-GluA1ct-infused offspring of low LG dams: n=7 rats; Tat-Ctrl-infused offspring of high LG dams: n=5 rats; Tat-GluA1ct-infused offspring of high LG dams: n=5 rats) *P< 0.05.