Figure 5.

Circling behavior following acute methamphetamine. (a) Intraperitoneal METH induces some, albeit insignificant, circling ipsilateral to a control ACSF infusion through a unilateral guide cannula. When BD-1063 is dissolved in the ACSF cannula infusion, a systemic METH injection produces profound ipsilateral circling. Unilateral BD-1063 infusion without METH injection fails to induce ipsilateral circling on its own. (b) Systemic METH appears to induce increased locomotor activity. This increase does not appear to be attenuated by cannula infusion of BD-1063 dissolved in ACSF. (c) Anatomical charts showing location of guide cannulas. Asterisk (*) represents significance level p<0.05. ACSF, artificial cerebrospinal fluid; METH, Methamphetamine.