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. 2018 Jan 24;43(6):1247–1256. doi: 10.1038/npp.2017.298

Table 2. Genotype Frequencies and Scoring for Each Polymorphism.

Polymorphism Genotypes n Frequency DA-related composite score
        Additive Dominant
DAT1 VNTR 9/9 16 0.17 High High
  9/10 36 0.38 Intermediate High
  10/10 42 0.45 Low Low
COMT rs4680 Met/met 25 0.27 High High
  Met/val 41 0.44 Intermediate High
  Val/val 28 0.30 Low Low
DRD2 rs1076560 T/T 1 0.01 High High
  T/G 27 0.29 Intermediate High
  G/G 66 0.70 Low Low
DRD4 VNTR Long/long 3 0.03 High High
  Long/short 29 0.31 Intermediate High
  Short/short 61 0.65 Low Low

For the DA-related genetic composite measure, two scoring models were evaluated. For the additive model, “high” genotypes (two alleles associated with higher DA tone) were scored as 2, “intermediate” genotypes as 1, and “low” genotypes as 0, and the total possible score ranged from 0 (no higher DA alleles) to 8 (all higher DA alleles). For the dominant model, homozygous “high” genotypes and heterozygous “intermediate” genotypes were each scored as 1 and “low” genotypes as 0, and the total possible score ranged from 0 (homozygous for all lower DA alleles) to 4 (homozygous or heterozygous for all higher DA alleles).