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. 2018 Mar 14;43(6):1257–1266. doi: 10.1038/npp.2017.301

Figure 3.

Figure 3

Effects of the candidate drug, pergolide, on binge drinking in High Drinking in the Dark (HDID-1) mice. Pergolide significantly reduced binge-like ethanol (20%) intake (a) and blood alcohol levels (BALs) (b). Pergolide also significantly reduced water (c) and 8.5 mM saccharin (d) intake but did not alter locomotor activity (e). Results of Tukey’s post-hoc analysis are indicated above the SEM bars (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001vs the 0-dose groups). Values represent mean ±SEM (Drinking assays: n=12–24/sex/dose; data shown are collapsed on sex, thus each bar represents 24–47 mice; Activity assay: n=7–8/sex/dose).