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BRG1 and Sox10 overexpression specifically decrease the motivation to take heroin. (a) Overexpression of Sox10 or BRG1 (via lenti-Sox10 or lenti-BRG1, respectively) did not alter the mean numbers of infusions self-administered per session (0.07 mg/kg per infusion). Overexpression of Sox10 or BRG1 resulted in decreased numbers of total active responses (b) and infusions earned (c) during the 6 h progressive ratio (PR) test. Data are expressed as means±SEMs. *P<0.05, **P<0.01.
