Table 3.

Particle size and zeta potential of PEI-PLA/PTX/siRNA/PEG-PAsp nanoparticles at different pH values revealed pH-dependent attachment and disattachment of PEG-PAsp under acidic conditions

PEI-PLA/PTX/siRNA/PEG-PAsp	Size (nm)	Zeta potential (mV)	PDI
pH 5.0	67.1±2.3	20.8±2.6	0.064
pH 6.0	72.3±1.4	19.2±1.8	0.121
pH 7.0	78.9±1.9	9.7±1.5	0.202
pH 8.0	81.5±2.2	4.3±0.4	0.144

Abbreviations: PEI-PLA, polyethyleneimine-block-polylactic acid; PTX, paclitaxel; PEG-PAsp, poly(ethylene glycol)-block-poly(L-aspartic acid sodium salt); PDI, polydispersity index.