Figure 2.

Steps in the stages of elicitation and resolution of the contact dermatitis. (1) After reexposure to the haptens, antigen- specific T-cell infiltration occurs, favored by the production of chemokines and cytokines through keratinocytes, mast cells, and neutrophils. (2) The Th1, Th17, ou T CD8+ antigen- specific T cells, which secrete IFN-γ (Tc1) or IL-17 (Tc17), produce cytokines that induce the infiltration of additional inflammatory cells. (3) In the resolution stages, the Tregs infiltrate in the inflammatory sites and perform a suppressor function, contributing to the finalization of the inflammatory response