Fig. 3.

Antagomir-148a treatment moderately ameliorates pathology of colitis. Colitis was induced in Rag1^−/− mice prior to their treatment with antagomirs as shown in Fig. 1A. (A) The weight loss relative to starting weight was monitored during the experiment. (B) At the end of the experiment, mice were sacrificed and the weight-to-length (W–L) ratios of the colons were determined. Displayed data are pooled from two independent experiments. The Two-Way ANOVA test was used to determine the overall statistical significance of total body-weight loss curves between antagomir-148a- and antagomir-Scr-treated mice. Bonferroni multiple comparison was used as a post-hoc test to evaluate the significance of single time points. Shown data are pooled from two independent experiments with n = 12 and n = 13 for antagomir-148a- and antagomir-Scr-treated mice, respectively. Depicted curves in (A) represent the median weight per designated group.