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. 2018 Apr 11;49(5):1223–1231. doi: 10.1161/STROKEAHA.117.019687

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© 2018 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — Complex I (C-I) impairment is associated with the multiphasic pattern of respiratory decline observed in ischemia/reperfusion (I/R). A, Overall activity of C-I at critical time points after I/R in mitochondrial membranes. B, In vitro time course of the reductive inactivation of NADH:hexaammineruthenium (HAR) reductase activity in mitochondrial membranes. Ischemic over-reduction of the ETC resulted in a decrease of the relative amount of C-I (red line) compared with control (black line). Addition of reduced FMN restored NADH:HAR reductase activity (arrow). C, Decrease of FMN in mitochondrial membranes obtained from the ischemic area after 35 minutes of middle cerebral artery occlusion (MCAO) compared with sham controls (n=6–12 per group; P=0.0048; ANOVA). n.s. indicates not signficant.