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. 2018 Apr 11;49(5):1223–1231. doi: 10.1161/STROKEAHA.117.019687

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© 2018 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 5. — Glutathione (GSH) ester treatment improves complex I (C-I)–mediated bioenergetic failure early after reperfusion. A, GSH ester treatment ameliorates mitochondrial respiratory decline at 30 minutes of reperfusion (n=5–6 per group; P=0.03; Mann–Whitney U test). B, C-I activity is significantly improved in GSH-treated mice compared with controls (n=5–6 per group; P<0.05; Mann–Whitney U test). C, No change in the relative amount of C-I was observed. D, In vitro pre-incubation of whole tissue homogenates with GSH was able to partially recover ischemia/reperfusion (I/R)-induced C-I activity decline 30 minutes after reperfusion (n=4 per group; P=0.0009; t tests). GSH treatment did not affect C-I activity in sham, 1 or 24 hours after reperfusion. MCAO indicates middle cerebral artery occlusion.