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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Exp Neurol. 2018 Mar 5;304:82–89. doi: 10.1016/j.expneurol.2018.03.001

Figure 2.

Figure 2

Single layer confocal images of gray matter of the cervical cord. In transgenic CST-YFP mice, the CST axons are fluorescent yellow-green under a laser-scanning confocal microscopy (A-C). Thirty-two days after right MCAo, compared to normal mice (A), YFP-positive CST axonal density was reduced in the denervated side of the cervical gray matter (B and C), while axons crossing the midline into the denervated left side from the right intact side were evident in the tPA treated mice (C). Quantitative analysis of the percentage of CST axons in the denervated side to the contralateral side demonstrated that intranasal tPA treatment significantly increased axonal density in the denervated gray matter (D, n=10 per group, p<0.0