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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Cephalalgia. 2017 Oct 12;38(8):1471–1484. doi: 10.1177/0333102417737778

Figure 6.

Figure 6

The sGC inhibitor, ODQ, inhibited NTG-induced basal and post-treatment hyperalgesia. Mice were treated chronically with vehicle (VEH) or NTG (10 mg/kg IP) every second day for 9 days. Prior to NTG/VEH administration, animals were injected with vehicle or ODQ (1 mg/kg, IP). (A) Basal responses, as assessed prior to drug treatment, were significantly decreased following NTG treatment, an effect that was completely blocked by ODQ. ***p<0.001 as compared to VEH-VEH controls. p< 0.001 effect of drug, time and interaction, 2-way RM ANOVA with Holm-Sidak post-hoc analysis. (B) Two hours following each injection, NTG-evoked a severe post-treatment hyperalgesia, which was completely prevented by ODQ treatment. p<0.001 effect of drug, no significant effect of time or interaction. n=9-15 mice/group.