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. 2018 Mar 6;10(3):380–396. doi: 10.1080/19420862.2018.1433976

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© 2018 Celltrion Inc., Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Size-exclusion chromatogram and multi-angle light scattering chromatogram of CT-P10, EU-Rituximab and US-Rituximab. (A) SEC-HPLC chromatograms detected at 214 nm are compared for 1 batch of each product. High molecular weight (HMW) and low molecular weight (LMW) variants are separated from monomer peak. (B) SEC-MALS chromatograms detected by UV (green), RI (purple) and LS (red) are compared for 1 batch of each product. Three HMW variants (Peak 1, Peak 2 and Peak 3) are present in EU- and US-Rituximab, whereas Peak 3 is not observed in CT-P10.