Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 6;10(3):380–396. doi: 10.1080/19420862.2018.1433976

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Celltrion Inc., Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

PMC Copyright notice

Figure 5. — Correlation between afucosylation level of CT-P10 with FcγRIIIa binding affinity and ADCC activity. (A) Spiking study using highly afucosylated CT-P10 (red) to check impact of variously afucosylated levels on FcγRIIIa binding affinity (left) and ADCC activity (right). Strong correlation is observed between afucosylation and biological activity when afucosylation level is increased up to 35%. (B) Relation between afucosylation level versus FcγRIIIa binding affinity (left) and ADCC activity (right) for CT-P10 (blue), EU-Rituximab (grey) and US-Rituximab (yellow) used in 3-way similarity study. Correlation between afucosylation and biological activity is not significant in the afucosylation level (< 5%) in CT-P10 drug product and RMPs.