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. 2018 Feb 20;10(3):335–345. doi: 10.1080/19420862.2018.1433973

Figure 1.

Figure 1.

Organic (denaturing) SEC/MS of conventional cysteine chemistry ADC: a) UV profile; b) zero-charge deconvoluted mass spectrum of early eluting peak 1; c) zero-charge deconvoluted mass spectrum of later eluting peak 2. Abbreviations: H denotes heavy chain, L denotes light chain, HL denotes heavy chain linked to light chain via interchain disulfide, HH denotes two heavy chains linked via hinge-region disulfides, HHL denotes two heavy chains linked via hinge-region disulfides and to light chain via interchain disulfide, and a number LP denotes a number of LP moieties. *represent a method artifact that pertains to in-source fragmentation of LP.