Table 1. C. elegans HSN and mouse raphe serotonergic neuron homology.
| C. elegans gene name | Description | Mammalian gene name |
|---|---|---|
| Serotonergic biosynthetic pathway | ||
| bas-1 a | Dopamine decarboxylase | Ddc |
| cat-1a | Vesicular monoamine transporter | Slc18a2 |
| cat-4 | GTP cyclohydrolase 1 | Gch1 |
| tph-1 a | Tryptophan hydroxylase | Tph2 |
| Axon guidance and Migration | ||
| ebax-1 a | Elongin-B/C E3 ligase | Zswim5/6/8 |
| egl-43 a | PR domain containing | Prdm16 |
| fmi-1 | Flamingo homolog | Celsr2/3, Fat1/3, Dchs1 |
| madd-2 a | Trim protein | Trim9/36/46, Fsd1/1 l, Mid2 |
| mau-2 a | Chromatid cohesion factor | Mau2 |
| mig-10 a | Protein with an RA-like, PH domains and proline-rich motif | Raph1, Grb10 |
| nck-1 | SH2/SH3 domain-containing protein | Nck1 |
| rig-6 a | neuronal IgCAM | Cntn1, 2, 3, 4, 5, 6 |
| tbb-4 a | Tubulin | Tubb2a/2b/4a/4b/5 |
| unc-40 a | Netrin receptor | Dcc, Neo1 |
| unc-51 a | Serine/threonine protein kinase | Ulk1/2 |
| unc-53 a | Neuron navigator | Nav1/2/3 |
| Neurotransmission/Synaptogenesis | ||
| abts-1 a | Anion/Bicarbonate Transporter family | Slc4a7/8/10 |
| clh-3 | Voltage sensitive cloride channel | Clcn2 |
| eat-16 | Regulator of G protein signaling | Rgs11/19 |
| gar-2 a | G-protein-coupled acetylcholine receptor | Hrh3 |
| ggr-2 a | GABA/Glycine Receptor | Glra1/2, Glrb |
| glr-5 a | Glu Receptor | Grid1/2, Grik1 |
| gsa-1 a | G protein, Subunit Alpha | Gnal, Gnas |
| ida-1 a | Protein tyrosine phosphatase-like receptor | Ptprn, Ptpm2 |
| irk-1 a | Inward Rectifying K (potassium) channel family | Kcnj3/5/6/9/11/16/ |
| kcc-2 a | K/Cl cotransporter | Slc12a5/6 |
| mpz-1 a | Multiple PDZ domain protein | Mpdz, Pdzd2, Inadl, Lnx1 |
| nhx-5 | Na/H exchanger | Slc9a6/7/9 |
| nid-1 a | Nidogen (basement membrane protein) | Lrp1/1b |
| nra-4 | Nicotinic Receptor Associated | Nomo1 |
| rsy-1 | Regulator of synapse formation | Pnisr |
| syg-1 a | Ig transmembrane protein | Kirrel, Kirrel3 |
| nlg-1 a | Neuroligin family | Nlg1/2/3 |
| unc-2 a | Calcium channel alpha subunit | Cacna1a/1b/1e |
| unc-77 | Voltage-insensitive cation leak channel | Nalcn |
| unc-103 a | K + channel | Kcnh2/7 |
| Transcriptional regulation | ||
| ceh-20 a | PBX TF | Pbx1/2/3 |
| egl-44 a | TEA domain TF | Tead1 |
| gei-8 | Nuclear receptor co-repressor | Ncor1 |
| hlh-3 a | bHLH TF | Ascl1 |
| ife-4 a | Initiation factor 4E | Eif4e2 |
| sem-4 a | Spalt TF | Sall2,Zfp236/Znf236 |
| Morphogenetic pathways | ||
| dsh-1 a | Homolog of disheveled | Dvl1/3 |
| plr-1 a | Ring finger protein | Rnf215 |
| prkl-1 a | Drosophila Prickle homolog | Prickle1/2 |
| sel-10 a | Suppressor/Enhancer of Lin-12(Notch) | Fbxw7 |
| Others | ||
| aak-2 a | AMP-activated protein kinases | Prkaa1/2 |
| ags-3 | G protein singalling modulator | Gpsm1 |
| aho-3 a | Hydrolase | Abhd17a/17b |
| ari-1 | Ubiquitin-protein transferase | Arih1 |
| arr-1 | G protein singaling adaptor | Arrb1/2 |
| arrd-17 a | Arrestin domain protein | Arrdc3 |
| baz-2 | Bromodomain adjacent to zinc finger domain | Baz2a/2b |
| elpc-1 | Elongator complex protein component | Ikbkap |
| elpc-3 | Elongator complex protein component | Elp3 |
| goa-1 a | G protein,O, Alpha subunit | Gnao1 |
| kin-20 | Protein kinase | Csnk1d/1e |
| puf-9 | Pumilio/FBF domain-containing | Pum1/2 |
| pxf-1 a | Rap guanine nucleotide exchange factor | Rapgef2/6 |
| rep-1 | Rab escort protein | Chm, Chml |
| ten-1 a | Type II transmembrane EGF-like repeats | Tenm1/3/4 |
|
top-1 a
a : gene with assigned HSN regulatory signature |
Topoisomerase | Top1/1mt |