. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: Nephrology (Carlton). 2019 Jan;24(1):81–87. doi: 10.1111/nep.13187

Table 3.

The effect of dialysis frequency on bicarbonate (HCO3⁻) levels in the subset of euthyroid FHN participants and the overall cohort.

	Euthyroid Participants^#		Overall Participants^#
	HCO3⁻ estimate (95% CI)	P	HCO3⁻ estimate (95% CI)	P
DAILY Trial^*
3x/week	0.28 (−0.52 to 1.08)	0.49	0.25 (−0.51 to 1.01)	0.52
6x/week	1.21 (0.43 to 1.99)	0.003	1.11 (0.36 to 1.86)	0.004
Treatment Difference	0.92 (0.04 to 1.81)	0.04	0.86 (0.02 to 1.70)	0.045
NOCTURNAL Trial^*
3x/week	0.31 (−1.15 to 1.78)	0.67	0.12 (−1.19 to 1.44)	0.85
6x/week	3.56 (1.97 to 5.15)	<0.001	3.11 (1.77 to 4.45)	<0.001
Treatment Difference	3.25 (1.46 to 5.04)	0.001	2.99 (1.41 to 4.56)	<0.001

Mixed model analysis (for Daily Trial, adjusted for clinical center).

Mean change from baseline within three times per week (3x/week) and six times per week (6x/week) hemodialysis and treatment effect (95% confidence Interval)