Table 2.
Methylation of promoters of the PTEN gene and PTENP1 pseudogene in normal, hyperplastic, and malignant endometrial tissues
| Gene | Blood |
Normal endometrium, mean age (extreme values) |
Hyperplasia without atypia |
Hyperplasia with atypia |
Endometrial carcinoma |
|
|---|---|---|---|---|---|---|
| 24 (17–34) | 52.5 (45–65) | |||||
| PTEN | 0.00 (0/25)* | 0.00 (0/24) | 0.00 (0/19) | 0.00 (0/30) | 0.00 (0/13) | 0.00 (0/57) |
| PTENP1 | 0.00 (0/25)* | 4.17 (1/24) | 57.89 (11/19) | 73.33 (22/30) | 76.92 (10/13) | 70.83 (17/24)** |
| P | < 0.001*** | < 0.351**** | < 0.450**** | < 0.521**** | ||
Note. Two-sided Fisher exact test.
*First digit – a percentage of methylated DNA samples; second digit – the number of methylated samples; third digit – the total number of samples.
**A subgroup of patients with age similar to that of the reference control group was selected from the main group of 57 patients with EC.
***Normal endometrium 24 (17–34) vs. 52.5 (45–65).
****Compared to normal endometrium 52.5 (45–65).