Table 1.
Comparison of the performance of different polygenic risk scores (PRS)
| Model | # of SNPs | SNP panel | Odds ratio source | PRS, Mean (SD) | AUC (95% CI) | |
|---|---|---|---|---|---|---|
|
| ||||||
| Case | Control | |||||
| 1 | 75 | BCAC [6] | WHI [17] | −0.017 (0.539) | 0.021 (0.530) | 0.520 (0.501–0.539) |
|
| ||||||
| 2 | 75 | BCAC [6] | AABC [13,12] | −0.012 (0.351) | 0.015 (0.352) | 0.520 (0.501–0.539) |
|
| ||||||
| 3 | 77 | BCAC [6] | BCAC [6] | −0.013 (0.425) | 0.016 (0.417) | 0.516 (0.497–0.535) |
|
| ||||||
| 4 | 93 | BCAC [6,2] | BCAC [6,2] | −0.024 (0.563) | 0.029 (0.549) | 0.525 (0.506–0.544) |
|
| ||||||
| 5 | 45 | SNPs with the effect in same direction between WHI and AABC | WHI [17] | −0.022 (0.457) | 0.027 (0.446) | 0.528 (0.509–0.547) |
| 6 | AABC [13,12] | −0.010 (0.310) | 0.012 (0.305) | 0.519 (0.500–0.538) | ||
|
| ||||||
| 7 | 34 | SNPs with the effect in same direction among WHI, AABC and BCAC | WHI [17] | −0.023 (0.423) | 0.028 (0.419) | 0.531 (0.512–0.550) |
| 8 | AABC [13,12] | −0.011 (0.292) | 0.013 (0.290) | 0.522 (0.503–0.540) | ||
| 9 | BCAC [6,2] | −0.018 (0.413) | 0.022 (0.398) | 0.524 (0.506–0.543) | ||
Abbreviation: WHI, Women’s Health Initiative (African American); AABC, African-American Breast Cancer GWAS study; BCAC, Breast Cancer Association Consortium; ROOT, GWAS of Breast Cancer in the African Diaspora; AUC, area under the receiver operating curve; CI, confidence interval.