Table 2.

Performance of polygenic risk scores by family history of breast cancer, and joint model of polygenic risk score and family history of breast cancer

Model	# of SNPs	Odds ratio source	AUC (95% CI)		AUC (95% CI)* FH + PRS (N=3186)
			With FH (N=439)	No FH (N=2747)
1	75	WHI [17]	0.554 (0.497–0.610)	0.516 (0.494–0.537)	0.552 (0.532–0.572)
2	75	AABC [13,12]	0.558 (0.502–0.613)	0.512 (0.490–0.533)	0.549 (0.529–0.569)
3	77	BCAC [6]	0.558 (0.503–0.613)	0.503 (0.481–0.525)	0.543 (0.522–0.563)
4	93	BCAC [6,2]	0.554 (0.499–0.609)	0.515 (0.493–0.537)	0.552 (0.532–0.572)
5	45	WHI [17]	0.585 (0.530–0.640)†	0.519 (0.498–0.541)	0.555 (0.535–0.575)
6		AABC [13,12]	0.570 (0.514–0.626)	0.514 (0.492–0.536)	0.551 (0.531–0.571)
7	34	WHI [17]	0.586 (0.532–0.640)†	0.521 (0.500–0.543)	0.557 (0.537–0.577)
8		AABC [13,12]	0.568 (0.513–0.623)	0.515 (0.493–0.536)	0.551 (0.531–0.571)
9		BCAC [6,2]	0.557 (0.501–0.612)	0.520 (0.498–0.541)	0.555 (0.535–0.575)

^*ROC analysis of joint model of family history and polygenic risk score

^†P<0.05 in the heterogeneity test comparing AUCs in subjects with or without family history of breast cancer.

Abbreviation: WHI, Women’s Health Initiative (African American); AABC, African-American Breast Cancer GWAS study; BCAC, Breast Cancer Association Consortium; ROOT, GWAS of Breast Cancer in the African Diaspora; AUC, area under the receiver operating curve; CI, confidence interval; FH, family history of breast cancer