Table 3.

Performance of the 93-SNP and 34-SNP polygenic risk scores by selected demographic characteristics

	93-SNP polygenic risk score		34-SNP polygenic risk score
	AUC (95% CI)	OR (95% CI)*	AUC (95% CI)	OR (95% CI)*
Age group, years
< 40	0.534 (0.495–0.573)	1.15 (1.00–1.32)	0.541 (0.503–0.580)	1.23 (1.03–1.46)
40–59	0.514 (0.486–0.542)	1.06 (0.96–1.17)	0.522 (0.494–0.549)	1.13 (0.99–1.28)
≥ 60	0.533 (0.499–0.566)	1.12 (1.00–1.26)	0.534 (0.500–0.568)	1.18 (1.01–1.37)
P for heterogeneity		0.58		0.74
Ethnicity
Nigerian	0.554 (0.523–0.585)	1.23 (1.10–1.38)	0.538 (0.507–0.569)	1.20 (1.03–1.40)
African American/African Barbadian	0.508 (0.484–0.531)	1.04 (0.96–1.13)	0.527 (0.503–0.550)	1.15 (1.04–1.28)
P for heterogeneity		0.019		0.64
Family history of breast cancer
Yes	0.554 (0.499–0.609)	1.22 (1.00–1.49)	0.586 (0.532–0.640)	1.39 (1.14–1.70)
No	0.515 (0.493–0.537)	1.07 (0.99–1.15)	0.521 (0.500–0.543)	1.08 (1.00–1.17)
P for heterogeneity		0.22		0.022

^*odds ratio per unit standard deviation of the polygenic risk score

Abbreviation: AUC, area under the receiver operating curve; CI, confidence interval; OR, odds ratio