Table 4.

Association of polygenic risk scores and breast cancer risk by estrogen receptor status

	Odds ratio (95% confidence intervals)
	All breast cancers	ER+ disease	ER− disease
93-SNP PRS
Per unit SD of PRS	1.10 (1.03–1.17)	1.17 (1.05–1.30)	1.04 (0.93–1.16)
Percentile of PRS
<5	0.72 (0.52–1.01)	0.68 (0.38–1.20)	0.65 (0.37–1.16)
5–10	0.84 (0.60–1.16)	0.63 (0.34–1.16)	0.74 (0.42–1.30)
10–20	0.78 (0.60–1.00)	0.81 (0.53–1.23)	0.95 (0.64–1.41)
20–40	0.83 (0.68–1.02)	0.89 (0.63–1.24)	0.70 (0.49–1.00)
40–60	1.00 (ref)	1.00 (ref)	1.00 (ref)
60–80	0.91 (0.74–1.11)	0.94 (0.67–1.32)	0.79 (0.56–1.11)
80–90	0.98 (0.76–1.26)	0.94 (0.62–1.43)	0.91 (0.60–1.38)
90–95	1.14 (0.82–1.57)	1.30 (0.79–2.15)	0.90 (0.52–1.58)
>95	1.11 (0.80–1.54)	1.54 (0.96–2.48)	0.94 (0.55–1.63)
P for trend	0.002	0.002	0.31
34-SNP PRS
Per unit SD of PRS	1.13 (1.06–1.20)	1.14 (1.03–1.27)	1.11 (1.00–1.24)
Percentile of PRS
<5	0.65 (0.46–0.90)	0.67 (0.39–1.16)	0.72 (0.38–1.36)
5–10	0.73 (0.53–1.02)	0.43 (0.22–0.84)	1.69 (1.04–2.76)
10–20	0.74 (0.58–0.96)	0.71 (0.47–1.08)	1.00 (0.63–1.56)
20–40	0.99 (0.81–1.21)	0.96 (0.69–1.33)	1.34 (0.94–1.93)
40–60	1.00 (ref)	1.00 (ref)	1.00 (ref)
60–80	0.90 (0.73–1.11)	0.77 (0.55–1.08)	1.07 (0.73–1.55)
80–90	1.04 (0.81–1.33)	0.94 (0.62–1.41)	1.42 (0.92–2.19)
90–95	0.95 (0.69–1.32)	0.88 (0.52–1.50)	1.31 (0.75–2.27)
>95	1.29 (0.94–1.79)	1.54 (0.96–2.47)	2.13 (1.28–3.53)
P for trend	<0.001	0.009	0.076

Abbreviation: SNP, single nucleoid polymorphism; PRS, polygenic risk score; ER, estrogen receptor; SD, standard deviation