Table 1.
Demographics and Cognitive Screening, Episodic Memory, and Paced Finger-Tapping Performances by Group
ε4− (n = 65) | ε4+ (n = 41) | MCI^ (n = 24) | F | p | ηp2 | (p’s < .05) | ||||
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
Mean | SD | Mean | SD | Mean | SD | |||||
Demographics | ||||||||||
Age (years) | 73.3 | 5.1 | 72.2 | 4.9 | 75.5 | 6.6 | 3.01 | .053 | .045 | |
Education (years) | 14.5 | 2.4 | 15.6 | 2.8 | 14.4 | 2.7 | 2.56 | .081 | .039 | |
Sex (male/female) | 19/46 | 14/27 | 6/18 | 0.64a | .726 | .070b | ||||
| ||||||||||
Cognitive Screening | ||||||||||
MMSE ( /30) | 29.3 | 0.8 | 29.1 | 1.1 | 27.3 | 2.1 | 22.66c | <.001 | .263 | MCI < ε4−, ε4+ |
DRS-2 | ||||||||||
Attention ( /37) | 36.5 | 0.7 | 36.4 | 0.8 | 35.6 | 1.5 | 7.84 | .001 | .110 | MCI < ε4− |
Initiation/Perseveration ( /37) | 36.8 | 0.5 | 36.5 | 1.8 | 34.3 | 2.7 | 20.44c | <.001 | .243 | MCI < ε4−, ε4+ |
Construction ( /6) | 5.9 | 0.2 | 6.0 | 0.2 | 5.8 | 0.4 | 3.97 | .021 | .059 | ns |
Conceptualization ( /39) | 37.2 | 2.5 | 37.3 | 1.8 | 36.1 | 2.3 | 1.36d | .261 | .021 | |
Memory ( /25) | 24.1 | 1.1 | 24.1 | 1.4 | 19.4 | 4.1 | 50.82 | <.001 | .445 | MCI < ε4−, ε4+ |
Total ( /144) | 140.5 | 2.9 | 140.0 | 3.7 | 131.2 | 7.0 | 42.70d | <.001 | .402 | MCI < ε4−, ε4+ |
| ||||||||||
Episodic Memory | ||||||||||
RAVLT | ||||||||||
Trials 1–5 ( /75) | 48.6 | 8.8 | 46.2 | 8.8 | 29.8 | 7.7 | 38.24c | <.001 | .376 | MCI < ε4−, ε4+ |
Immediate Recall ( /15) | 9.8 | 2.6 | 8.4 | 2.5 | 4.1 | 2.5 | 39.65c | <.001 | .384 | MCI < ε4−, ε4+; ε4+ < ε4− |
Delayed Recall ( /15) | 9.8 | 2.7 | 8.7 | 3.0 | 3.0 | 1.9 | 52.06c | <.001 | .451 | MCI < ε4−, ε4+; ε4+ < ε4− |
| ||||||||||
Paced Finger-Tapping (ms) | ||||||||||
M-ITI (meanx − target) | −21 | 66 | −35 | 52 | −71 | 88 | 0.93e | .399 | .014 | |
SD-ITI | 55 | 31 | 53 | 30 | 82 | 48 | 3.66ce | .029 | .054 | MCI > ε4−, ε4+* |
Note. ε4 = apolipoprotein E-epsilon 4; MCI = mild cognitive impairment; MMSE = Mini-Mental State Examination; DRS-2 = Dementia Rating Scale-2nd Edition; RAVLT = Rey Auditory Verbal Learning Test; ms = milliseconds; ITI = inter-tap interval.
9 ε4−, 15 ε4+.
Pearson Chi-Square Test.
Cramer’s V.
ANOVA results using standardized residual scores based on regression with age as a predictor.
ANOVA results using standardized residual scores based on regression with age and education as predictors.
Reciprocal square root data transformation.
p < .10.