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Placental ischemia leads to release of factors that play a role to pathophysiology of preeclampsia. Abbreviations: TH1 T helper cells type 1, TH2 T helper cells type 2, AT1-AA autoantibodies to angiotensin II type 1 receptor, ET-1 endothelin 1, sFlt-1 soluble vascular endothelial growth factor receptor 1, NO nitric oxide, IUGR uterine growth restriction
