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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Mod Pathol. 2017 Jun 16;30(9):1251–1261. doi: 10.1038/modpathol.2017.42

Figure 2.

Figure 2

BCOR expression in 2 cases of YWHAE-NUTM2 high-grade endometrial stromal sarcoma with unusual histology. A pulmonary metastasis composed of intermediate-grade fibromyxoid spindled cells with low mitotic index (a, b) exhibits strong and diffuse BCOR immunoexpression (c). Pleomorphic undifferentiated sarcoma (d, bottom left, f) composed of cells with marked nuclear pleomorphism, brisk mitotic activity, and atypical mitoses in a background of hyalinized stroma adjacent to high-grade endometrial stromal sarcoma (d, top right, e) demonstrating spindled cells with ovoid nuclei and prominent nucleoli vaguely whorling around delicate arterioles. The pleomorphic sarcoma component shows only focal weak to moderate cyclin D1 staining (g), but diffuse and strong BCOR expression (h). Separation of green 5′ and red 3′ signals and single green 5′ signals (i) confirm YWHAE rearrangement by break-apart fluorescence in situ hybridization.