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. 2018 Jan 28;7(2):47–59. doi: 10.1055/s-0038-1624577

Fig. 2.

Fig. 2

Evolutionary conservation of the amino acid residues ( a ) p.189, ( b ) p.218, ( c ) p.446, and ( d ) p.683 in PHEX. The novel PHEX mutations Q189Hfs*22, H218Sfs*2, F446*, and L683H occur at highly conserved positions in PHEX protein as shown by comparing the corresponding amino acid sequences of nine different species.