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. Author manuscript; available in PMC: 2018 Jul 13.
Published in final edited form as: J Med Chem. 2017 Jun 26;60(13):5556–5585. doi: 10.1021/acs.jmedchem.7b00239

Scheme 1.

Scheme 1

a) alkyl halide, K2CO3, DMF, 24 h, 35–72% (procedure I); b) substituted alcohol, DIAD, PPh3, Et3N, 6 days, 23–34% (procedure II); c) HCl/ether, 1 h, quant. (procedure III); d) chloroacetyl chloride, Et3N, DCM, 3 h, 52–72% (procedure IV); e) substituted phenol, Cs2CO3, ACN, 15 h, 58–92% (procedure V)