Fig. 1.

KG1a is resistant to chemotherapy and DNT therapy. a A dose titration of DNR, ranging from 0.025 to 0.8 μg/mL, and b AraC, ranging from 0.125 to 8 μg/mL, were performed on four different AML cell lines over 24 h and the proportion of cells killed by the drugs, determined by flow cytometry, is shown. c Cytotoxicity assays were performed on four different AML cell lines, which were co-cultured with DNTs for 2 h at varying effector-to-target (E:T) ratios. Specific killing of target cells by DNTs was calculated as described in the Methods section. Each point represents the mean + standard deviation (SD) of triplicate measurements from a representative experiment. Experiments were repeated twice with similar results